Journal article
An illustrated anatomical ontology of the developing mouse lower urogenital tract
KM Georgas, J Armstrong, JR Keast, CE Larkins, KM McHugh, EM Southard-Smith, MJ Cohn, E Batourina, H Dan, K Schneider, DP Buehler, CB Wiese, J Brennan, JA Davies, SD Harding, RA Baldock, MH Little, CM Vezina, C Mendelsohn
Development Cambridge | Published : 2015
DOI: 10.1242/dev.117903
Abstract
Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine models. However, human anatomical terms do not always superimpose on the mouse, and the lack of accurate and standardised nomenclature is hampering the utility of such animal models. We previously developed an anatomical ontology for the murine urogenital system. Here, we present a comprehensive update of this ontology pertaining to mouse LUT, genital tubercle and associated reproductive structures (E10.5 to adult). Ontology changes w..
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Awarded by National Institute of Diabetes and Digestive and Kidney Diseases
Funding Acknowledgements
The research of the authors was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [grant R01DK085242 to K.M.M.] and National Institutes of Health (NIH) grants [DK070136 to M.H.L.], [DK083425 to C.M.V.], [DK092983 to J.A.D. and R.A.B.], [DK094523 and ES017099 to M.J.C.], [UO1 DK094479 to J.R.K.], [R56 DK078158 R01 DK078158 and subcontract on U01 DK070219 to E.M.S.-S.]. M.H.L. is a National Health and Medical Research Council of Australia Senior Principal Research Fellow. Deposited in PMC for release after 12 months.